Abstract. BACKGROUND: Neonatal stroke is an important cause of neurodisability in childhood and in later life. Delay in diagnosis is often inevitable due to the non-specific presentation, the lack of clinical signs, and not considering stroke early enough in the differential diagnosis. CASE: We report the case of a baby who initially presented with apparent newborn “jitteriness” and abnormal movements. On the background of an unremarkable birth history and negative initial investigations, the baby subsequently developed focal seizures. The diagnosis was suspected to be neonatal stroke which was later confirmed on magnetic resonance imaging. CONCLUSION: General Movements assessment is an established useful tool used in the assessment of such babies and proves helpful in evaluating whether movements are normal or pathological, in addition to prognosticating outcome. Cranial ultrasound is a commonly employed first-line investigation, however, initial normal intracranial appearances do not exclude stroke. Magnetic resonance imaging is the gold standard but may not be immediately available to all practitioners.