Abstract. This is a case report, with review of the literature, of an infant in the neonatal intensive care unit (NICU) with thecomplication of a nasoenteric weighted feeding tube that assumed an overhand knot configuration. Knotting of the feeding tubeis a rare occurrence related to the use of feeding tubes, and should be considered if the tube becomes nonfunctional, if there areclinical factors that might lead to displacement or malposition of the tube, or if there is excessive resistance or sudden onset ofrespiratory distress in association with attempted removal.