Abstract. A 10 week old preterm infant was noted to have a vesiculo-pustular eruption on the face and scalp with an erythematous base. Initially the lesions were thought to be secondary to herpes simplex virus infection. However, skin biopsy confirmed the diagnosis of eosinophilic pustular folliculitis (EPF). This idiopathic skin disorder is rarely seen in neonates. To our knowledge this is the first reported case of EPF in a preterm infant.