Giant neonatal thoraco-abdominal lymphatic malformations treated with sildenafil: A case report and review of the literature

Abstract. Lymphatic malformations account for approximately 5% of benign tumors encountered during the neonatal period. Most often treated by surgical resection or sclerotherapy, phosphodiesterase inhibitors have recently emerged as a potential treatment modality for lymphatic malformations. Treatment with phosphodiesterase inhibitors may be particularly useful when patients are not candidates for surgical resection or sclerotherapy. We report a case of giant bilateral lymphatic malformations diagnosed prenatally and treated postnatally with sildenafil.

*Corresponding Author: 

Dr. Paul Singh, Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, University of Missouri Kansas City School of Medicine, 2301 Holmes Street, Kansas City, MO 64108, USA. Tel.: +1 816 404 5168; Fax: +1 816 404 5152; E-mail: