Staphylococcus aureus sepsis inducing severe hemolysis in glucose-6-phosphate dehydrogenase (G-6-PD)-deficient preterm infant causing severe neonatal jaundice and kernicterus

E. Al Awad∗, H. Obaid, K. Mohammad, H. Amin and A. Lodha | JNPM 2012;

Abstract. Kernicterus caused by severe jaundice is a devastating condition and has long-term neurodevelopmental consequences in children. Infections and drugs can trigger severe hemolysis in newborns with deficiency of glucose-6-phosphate dehydrogenase (G-6-PD), and can precipitously increase the severity of jaundice. In this case report, we speculate that Staphylococcus aureus sepsis may have triggered severe hemolysis in a G-6-PD-deficient preterm neonate, leading to severe neonatal jaundice and kernicterus. To our knowledge this is the first such reported case.

*Corresponding Author: 

Dr. Essa Hamdan Al Awad, University of Calgary, Division of Neonatology, Department of Pediatrics, Peter Lougheed Centre, 3500, 26th Ave, NW, Calgary, AB T1Y6J4, Alberta, Canada. Tel.: +1 403 943 4892; Fax: +1 403 943 2565; E-mail: